Unveiling the Role of Small Proteins in Model Organisms
We look to elucidate the mechanisms through which small proteins, approximately 50 amino acids in length, contribute to the regulation of stress responses in bacteria, with a particular focus on E. coli and B. subtilis. Our research revolves around exploring the role of these small proteins in modulating two-component systems, which serve as vital sensory and adaptive mechanisms in response to diverse external stimuli.
Identifying Regulatory Small Proteins
We recognize that there is a need for efficient functional characterization methods for small proteins. With over 100 small proteins already identified in E. coli, the process of determining their functionality is laborious. Hence, we are dedicated to developing and evaluating a novel screening methodology that not only expedites the identification of functional small proteins but also places special emphasis on those involved in regulating two-component systems, thus shedding light on their crucial role in bacterial adaptation.